Selection rows and fall-outs with previous Pakistan regimes mean that experienced batsman Misbah is now making his first Test tour of England at the advanced age of 42.
It was six years ago that Amir, new-ball partner Mohammad Asif and then-captain Salman Butt tarnished the reputation of Pakistan cricket with their involvement in a spot-fixing affair that saw the trio conspire to deliberately bowl no-balls during the 2010 Lord's Test against England.
All three were given five-year bans and jail sentences.
The intervening period has not been easy for Pakistan, who have had to get used to playing all their "home" matches in the United Arab Emirates because of security concerns arising from an armed attack on Sri Lanka's team coach in Lahore in 2009.
But under Misbah's shrewed guidance Pakistan have become tough to beat in the UAE and a competitive side abroad, traits reflected in their third place in the current world Test rankings -- one position above England.
Indeed they have yet to lose a Test series in their adopted home, with England beaten in two of those campaigns for an aggregate 5-0 scoreline in Pakistan's favour.
An experienced batsman who has had a calming effect on the players around him, Misbah has overseen the reintegration of Amir into the side.
Having coped with the understandable interest in Amir making his return to Test cricket at Lord's, the scene of the crime, Misbah had no problems in fending off enquiries about how long he intends to keep playing for Pakistan.
"My retirement has been discussed every series," Misbah told reporters at Lord's on Wednesday.
"I could have retired after the UAE against England (last year) -- but we've been playing together for six years.
"I decided I need to be here in a tough series for Pakistan, and I really want to do well here.