MillenniumPost
Opinion

Why should we be bothered with what ailed Japan in 1940

Japanese Encephalitis (JE) – so called as the deadly disease broke out first in the 1940s in Japan but has been contained since – is again claiming lives in Uttar Pradesh, Bihar and Assam in pockets in northern and eastern India.

Grey herons were found to be the avian reservoirs, rice field breeding mosquitoes the vector and pigs the amplifiers. The Japanese produced a vaccine and vaccinated all pigs. The infection ended. It never appeared again in Japan.

The first big JE epidemic in India occurred in North Arcot district of Tamil Nadu in 1957-1958, in Burdwan and Bankura in West Bengal (1976) and in Tirunelveli in Tamil Nadu (1978). One can expect JE epidemics in India year after year in regions subjected to prolonged drought-like conditions followed by heavy rains. This causes heavy mosquitogenic conditions.

In India, there are ‘pond herons’ (Ardeola grayii) and ‘cattle egrets’ (Bubulcus ibis) which share the similar niche. Pigs circulate high concentration of the virus and can infect a large number of mosquitoes.

The mosquitoes which pick up the infection are mainly zoophilic (i.e. they prefer to feed on animals including birds). The cattle can circulate virus but do not play any significant role in the transmission.

When the mosquito population increases enormously following heavy rains and floods, an odd mosquito – out of thousands – bites man. Unfortunately, an impending JE epidemic is recognised by the authorities only when the first human case is reported. It is too late.

It is now accepted that once JE infection is detected in man, there is no use carrying out any vector control measure.

This is because while in the case of malaria or filariasis a mosquito can pick up the infection from one man and transmit to another, this does not happen in JE.

The chances are very remote for the vectors of JE to transfer infection from man to man.

After getting a blood meal, the JE mosquito must wait till its egg-laying is complete – which takes 7-10 days – before it can bite another man. So the time to launch vector control measures is when the conditions are ripe for vectors to start biting humans, not after detecting the first case. In a country like India, where drought and floods occur periodically or with regular frequency, the occurrence of JE can be forecast. Large water pools ideal for breeding of vectors of JE are conducive for nesting and breeding of Ardeid birds such as egrets and herons. The mosquitoes are there, the avian hosts are there and in the adjacent villages cattle, poultry and pigs are present. JE will strike humans when all these factors co-exist. One can therefore predict with reasonable accuracy an impending epidemic. In fact, research on methods of predicting an epidemic should be a continuous process. Instead the authorities prefer to carry out fire-fighting operations during epidemics.

There does not seem to be a long term plan vis-a-vis JE control. The government’s efforts to produce an effective vaccine are laudable but the question is: to whom will this vaccine be given? To prevent recurrence of JE epidemics, the first priority is to delimit endemic areas where JE has occurred in the past.

The meteorological, animal husbandry, agricultural and revenue departments should coordinate their efforts to share data to predict any unusual changes in ecology and ecosystem. Once it is possible to predict an epidemic, effective use of insecticidal residual sprays will help slow down transmission, provided this is done before the epidemic starts.

For successful forecast, the existing district level entomological units under the National Malaria Eradication Programme should be fully equipped to monitor mosquito populations.

Strengthening the infrastructure to recognise cases immediately and transport them to the nearest hospital is the only way to save lives. JE cases will still occur but the intensity of the epidemic will be low and manageable. At least deaths can be prevented.

There is some missing knowledge that requires some research.

How and from where does the JE virus get introduced into an area where the epidemic occurs? What happens to the virus during the inter-epidemic period?

Even if the grey herons and some Ardeid birds are infected, how is the infection transferred to the fledglings? Are there other animals or birds involved in the natural cycle?

In recent years the Indian Council of Medical Research (ICMR) has been downgrading medical entomology as a subject by switching its focus to molecular biology. Even universities in India do not teach zoology or entomology these days, but only life sciences and biotechnology. [IANS]
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