Three scientists share 2013 medicine Nobel Prize
8 Oct 2013 5:31 AM IST
James Rothman, Randy Schekman and Thomas Sudhof were picked ‘for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells’, said Goran Hansson, Secretary of the Nobel Assembly at Swedish Karolinska Institute. Through their discoveries, Rothman, Schekman and Sudhof have revealed the exquisitely precise control system for the transport and delivery of cellular cargo, the assembly said in a statement.
Schekman identified three classes of genes that control different facets of the cell’s transport system, providing new insights into the tightly regulated machinery that mediates vesicle transport in the cell. Rothman discovered in the 1990s that a protein complex enables vesicles to dock and fuse with their target membranes and his findings together with Schekman’s discovery, revealed an ancient evolutionary origin of the transport system.
Sudhof’s research was based on the discovery of machinery by Schekman and Rothman and his discovery explained how temporal precision is achieved and how vesicles’ contents can be released on command, it added.
Schekman identified three classes of genes that control different facets of the cell’s transport system, providing new insights into the tightly regulated machinery that mediates vesicle transport in the cell. Rothman discovered in the 1990s that a protein complex enables vesicles to dock and fuse with their target membranes and his findings together with Schekman’s discovery, revealed an ancient evolutionary origin of the transport system.
Sudhof’s research was based on the discovery of machinery by Schekman and Rothman and his discovery explained how temporal precision is achieved and how vesicles’ contents can be released on command, it added.
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