Govt issues advisory for rational use of Remdesivir

New Delhi: The government on Monday issued an advisory for rational use of Remdesivir in COVID-19 treatment, underlining that the anti-viral drug must be advised by senior faculty members directly involved in the patient's care.

The drug should be provided by the hospitals, and patient's relatives should not be asked to procure it from the retail market, it said.

To stop the misuse of Remdesivir, the government further recommended that if the drug is to be advised or ordered during odd hours, it should be done by the duty doctor after a telephonic consultation with a senior faculty member, specialist or a unit in-charge, and that advise or order must be written and it should bear the name, signature and stamp of the doctor concerned.

According to the advisory, every hospital needs to set up a special drug committee (SDC) to review the use of Remdesivir at the facility periodically.

It would be preferable to have a pharmacology professor or faculty as a member of the SDC wherever available. The committee should share its findings with the clinicians periodically to ensure rational and judicious use of Remdesivir.

"Remdesivir should be procured and provided by the hospitals only; the patient's attendants/ relatives should not be asked to procure Remdesivir from retail market," the advisory underlined.

The MOHFW, AIIMS and the ICMR had jointly issued treatment guidelines for management of COVID-19 patients in the form of a guidance/algorithm on 23rd April.

But this guidance/algorithm does not prevent misuse/overuse of Remdesivir, the advisory said.

The purpose of this document is to stop irrational use or overprescription of the reserve/experimental/emergency-use authorisation drug Remdesivir.

For this reason, the Joint Monitoring Group, under the chairmanship of the Director General of Health Services, took into consideration findings of some studies to issue the advisory.

The studies he took note of are -- The 'Adaptive COVID-19 Treatment Trial' that found Remdesivir is useful in cases of COVID-19 with SpO2 lesser than 94 per cent on room air (moderate to severe cases) if it is administered within seven to 10 days of illness.

Remdesivir led to a shorter median time from randomisation to recovery (10 days versus 15 days with placebo) and may have reduced the time to hospital discharge (12 days versus 17 days) but did not show a mortality benefit, it showed.