The ATR plane PK-661 with 47 people crashed near Havelian while en route to Islamabad from Chitral in Khyber-Pakhtunkhwa province.
The national carrier's flight departed from Chitral at 3:30 PM (local time) and disappeared from the air control radar soon after take off, the Express Tribune reported.
According to military's media wing, army troops and helicopters have been dispatched to the crash site for rescue efforts.