Stockholm: Two scientists won the Nobel Prize for Chemistry on Wednesday for finding an ingenious new way to build molecules that can be used to make everything from medicines to food flavourings.
The work of Benjamin List of Germany and Scotland-born David WC MacMillan has allowed scientists to produce those molecules more cheaply, efficiently, safely and with significantly less environmental impact.
It's already benefiting humankind greatly, said Pernilla Wittung-Stafshede, a member of the Nobel panel.
Making molecules that require linking individual atoms together in specific arrangements is a difficult and slow task. Until the beginning of the millennium, chemists had only two methods or catalysts to speed up the process.
That all changed in 2000, when List, of the Max Planck Institute, and MacMillan, of Princeton University, independently reported that small organic molecules can be used to do the same job as big enzymes and metal catalysts.
The new method, known as asymmetric organocatalysis, "is used widely today, for example, in drug discovery and in fine chemicals production," said Wittung-Stafshede.
Johan Qvist, chair of the Nobel panel, called the new method as simple as it is ingenious.
The fact is that many people have wondered why we didn't think of it earlier, he added.
HN Cheng, president of the American Chemical Society, said the laureates developed new magic wands.
"Before the laureates' work, the standard catalysts frequently used were metals, which frequently have environmental downsides, said Cheng. They accumulate, they leach, they may be hazardous."
The catalysts that MacMillan and List pioneered are organic so they will degrade faster, and they are also cheaper, he said.
Peter Somfai, another member of the committee, stressed the importance of the discovery for the world economy.
It has been estimated that catalysis is responsible for about 35% of the world's GDP, which is a pretty impressive figure, he said. If we have a more environmentally friendly alternative, it's expected that that will make a difference.
Speaking after the announcement, List said the award was a "huge surprise".
"You really made my day today," the 53-year-old said by telephone to the journalists gathered for the announcement from his vacation in Amsterdam.
List said he did not initially know that MacMillan was working on the same subject and figured his hunch might just be a stupid idea until it worked.
"When I saw it worked, I did feel that this could be something big," he said of his eureka moment.
Since their discovery, the tool has been further refined, making it many times more efficient, said List, adding that the real revolution was only just beginning.
List said the award would allow him even greater freedom in his future work.
"I hope I live up to this, to this recognition and continue discovering amazing things,"
he said.
MacMillan had not yet been reached by the time of the announcement, said Goran Hansson, secretary-general of the Royal Swedish Academy of Sciences.