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Air pollution may lead to infertility in men

Air pollution - particularly levels of fine particulate matter - may affect sperm quality and lead to infertility in men, a study has warned. Environmental exposure to chemicals is thought to be a potential factor in worsening sperm quality, but the jury is still out on whether air pollution might also have a role.

To explore this possibility further, researchers from Chinese University of Hong Kong looked at the impact on health of short and long term exposure to fine particulate matter (PM2.5) among nearly 6,500 15 to 49 year old men in Taiwan. The men were all taking part in a standard medical examination programme between 2001 and 2014, during which their sperm quality was assessed.
PM2.5 levels were estimated for each man's home address for a period of three months, as that is how long it takes for sperm to be generated, and for an average of two years, using a new mathematical approach combined with NASA satellite data. A strong association between PM2.5 exposure and abnormal sperm shape was found. Every five microgramme per cubic metres increase in fine particulate matter across the two year average was associated with a significant drop in normal sperm shape/size of 1.29 per cent.
It was associated with a 26 per cent heightened risk of being in the bottom 10 per cent of normal sperm size and shape, after taking account of potentially influential factors, such as smoking and drinking, age or overweight. However, it was also associated with a significant increase in sperm numbers, possibly as a compensatory mechanism to combat the detrimental effects on shape and size, researchers said. Similar findings were evident after three months of exposure to PM2.5. This is an observational study so no firm conclusions can be drawn about cause and effect, and the researchers were not privy to information on any previous fertility problems.
Exactly how air pollution could impair sperm development is not clear. How many of the components of fine particulate matter, such as heavy metals and polycyclic aromatic hydrocarbons, have been linked to sperm damage in experimental studies, researchers said.
Free radical damage, brought on by exposure to air pollutants, might have a possible role.
"Although the effect estimates are small and the significance might be negligible in a clinical setting, this is an important public health challenge," said Xiang Qian Lao of the Chinese University of Hong Kong. "Given the ubiquity of exposure to air pollution, a small effect size of PM2.5 on sperm normal morphology may result in infertility," Lao said.

PTI

PTI

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